Football, War and Traumatic Brain Injury

The New England Journal of Medicine published a Perspective on Traumatic Brain Injury called "Traumatic Brain Injury - Football, Warfare, and Long-Term Effects."

In late July, the National Football League introduced a new poster to be hung in league locker rooms, warning players of possible long-term effects of concussions.  Public awareness of the pathological consequences of traumatic brain injury has been elevated not only by the recognition of the potential clinical significance of repetitive head injuries in such high-contact sports as American football and boxing, but also by the prevalence of vehicular crashes and efforts to improve passenger safety features, and by modern warfare, especially blast injuries.

The article, by Dekosky et al., N Engl J Med 2010; 363:1293-1296, Sept. 30, 2010, goes on to contrast immediate consequences of traumatic brain injury and how long they last with delayed consequences of traumatic brain injury.

Many complications of traumatic brain injury are evident immediately or soon after injury....Seemingly mild closed-head injuries (i.e., those without skull fracture) may lead to diverse and sometimes disabling symptoms, such as chronic headaches, dizziness and vertigo, difficulty concentrating, word-finding problems, depression, irritability, and impulsiveness. The duration of such symptoms varies but can be months. Post-traumatic stress disorder frequently accompanies traumatic brain injury, though the relationship is poorly understood.

However, "Causal relationships between traumatic brain injury and delayed sequelae have been less studied because of the variable latency period before overt neurologic dysfunction."  However that does not mean relationships do not exist.  We know of certain repetitive mild brain injury (boxers); pugilistic parkinsonism.

 "Neurocognitive effects of repetitive mild head injury were initially recognized in boxers, with a syndrome that was distinct from the clinical and pathological sequelae of single-incident severe traumatic brain injury." Now other contact sports and blast injuries are also known to impact the brain.  In severe cases, as soon as two hours after the injury, scientists have discovered a protein, also seen in Alzheimer's patients, that causes cellular degeneration in the brain.  However in "mild brain injuries" the protein plaque is not evident. 

Further studies will help us understand why.  Currently precursers of the protein are seen in "mild brain injury" studies.  And, repetitive injury is replete with evidence of pugilistic parkinsonism

 

Epilepsy in Soldiers With Brain Injuries

With the War in Iraq technically over, many veterans are returning home. 

The American Academy of Neurology reports Soldiers With Brain Injuries are at Higher Risk Of Epilepsy Years after Returning Home. 

The new research is published in the July 20, 2010, print issue of Neurology®, the medical journal of the American Academy of Neurology, entitled correlates of posttraumatic epilepsy 35 years following combat brain injury (cme). - Raymont, V., Salazar, A.M., Lipsky, R., Goldman, D., Tasick, G., Grafman, J.. Pages: 224-229.

This is certainly consistent with what I have posted about previously including previous studies and articles.  We have known for years that traumatic brain injury increases the chance of developing epilepsy.

Epilepsy is a general term for conditions with recurring seizures. There are many kinds of seizures, but all involve abnormal electrical activity in the brain that causes an involuntary change in body movement or function, sensation, awareness, or behavior.  Epilepsy can be caused by many different conditions that affect a person’s brain. Examples of these conditions include stroke, head trauma, complications during childbirth, infections (such as meningitis, encephalitis, cysticercosis, or brain abscess), and certain genetic disorders. Often, no definite cause can be found.

Epilepsy affects an estimated 2.5 million people in the United States and each year accounts for $15.5 billion in direct costs (medical) and indirect costs (lost or reduced earnings and productivity). More than one-third of people with epilepsy continue to have seizures despite treatment.

Each year, about 200,000 new cases of epilepsy are diagnosed in the United States. Children younger than age 2 years and adults older than age 65 are most likely to be affected. In addition, people of low socioeconomic status, those who live in urban areas, and members of some minority populations are at increased risk for epilepsy.
 

 

Which Way Home for War Weary Troops?

The way home for war weary troops is a revolving door between the States, Iraq and Afghanistan.  MSNBC recently reported the tragedy of Major Jeff Hall's and Joe Callan's multiple deployments to war torn zones with brief breaks at home in the United StatesFor many U.S. vets, life becomes a revolving door of war, home, then back to combat — where they again face the same dangers and stresses.

Nearly 300,000 troops have served, three, four or more tours of duty in Afghanistan or Iraq.  The signs, symptoms and consequences of multiple blast injuries to the brain and PTSD show up when soldiers come home and too often are misunderstood and neglected.

With two long wars — Afghanistan is in its ninth year and Iraq just entered its eighth — the U.S. military finds itself straining to maintain a steady flow of troops. More than 2 million men and women have been deployed to serve in both conflicts, and more than 40 percent of them have served at least two tours, according to military records.

Nearly 300,000 troops have served three, four or more times. And, records show, more than half of those currently at war are at least on their second tour. (The vast majority of deployments last more than six months.)

For these men and women, life becomes a revolving door of war, home, then back to combat — sometimes within months — as they face the same dangers, the same stresses and the same agonizing separation from family. Some soldiers are gone so often, they're more comfortable being away.

The article looks deeper into the issues surrounding these military men and women.

Hurt Locker and Blast Injuries

I just saw the Hurt Locker directed and produced by Kathryn Bigelow.  A movie about the solitude of explosive munitions neutralizer soldiers.  The entire movie portrays disarming Improvised Explosive Devices (IED) sometimes successfully and sometimes not.  The movie is nominated for an Oscar.

An IED is a device fabricated or placed in an improvised manner, incorporating lethal, noxious, pyrotechnic, or incendiary materials designed to destroy, incapacitate, harass, or distract. It may incorporate military parts, but is normally constructed from nonmilitary components.

What the movie does not provide is the reality these repeated trauma have on soldiers. 

To study such biomechanics and injury, the North American Brain Injury Society (NABIS) formed one of the first committees.   Blast Injury and TBI by Ronald C. Savage, EdD Executive Vice President, NABIS, states:

During the Vietnam War and the Persian Gulf War, 76 percent of American troops survived combat wounds. But in this century, the U.S. military's surgical teams "have saved the lives of an unprecedented 90 percent of the soldiers wounded in battle…" (New England Journal of Medicine, December, 2006). Furthermore, Walter Reed Army Medical Center reported that nearly 30% of all patients with combat-related injuries seen at Walter Reed from 2003 to 2005 sustained a TBI and that blast injuries are a significant cause of TBIs In addition, they reported that TBI is often associated with severe multiple trauma, post traumatic stress disorder (PTSD) or undiagnosed concussions. Thus, screening soldiers who are at risk for a TBI is important in order to ensure that TBIs are identified and appropriately treated.

Diagnosis can be difficult even when TBI is apparent or the patient is able to describe a concussive head injury to their doctors. The more common mild brain injury often has more than mild consequences and can cause depression, reduced cognitive functioning, nausea,
sleep disturbance, erratic behavior, and mood swings. These impairments are exacerbated by misdiagnosis, lack of treatment and the public’s misperceptions about brain injury and mental illness. For veterans with brain injuries, the lack of physical signs and the diffuse nature of symptoms may be met with skepticism, considered to be psychological, or worse, malingering.

As professionals in the field know, the “walking wounded” do not disappear. And many more will be seen and heard in this decade. Thanks to improvements in protective gear and swift medical treatment, more of America's wounded are surviving - and returning home with serious, permanent injuries. How will these veterans fare in the routines of daily life? Will they be able to maintain employment? How will their injuries impact their families, friends, co-workers, and communities?

The North American Brain Injury Society has begun to address these important issues. We recently published a special edition of Brain Injury Professional that focused solely on blast injury and TBI. NABIS would like to extend our sincere appreciation and thanks to Representative Bill Pascrell, co-chair of the Congressional Brain Injury Task Force, who wrote a thoughtful introduction, and also to Dr. Tina Trudel who served as Guest Editor.

In addition, the Planning Committee of our 2007 conference has organized a number of sessions devoted to the topic of blast injury. NABIS will continue to explore additional ways that we can create positive change in this area and we look forward to sharing those ideas with our membership in the future. 
 

Susan Lance, a speech pathologist specializing in •developmental problems •strokes
•brain injuries and •other neurological disorders, states, 

 

PTSD and MTBI in Veterans Study

Pietrzak and colleagues published their study in the Journal of Nervous and Mental Disease (Posttraumatic Stress Disorder Mediates the Relationship Between Mild Traumatic Brain Injury and Health and Psychosocial Functioning in Veterans of Operations Enduring Freedom and Iraqi Freedom. Journal of Nervous and Mental Disease, 2009;197(10):748-753).

The study, from Yale University, evaluated whether posttraumatic stress disorder (PTSD) mediated the relationship between mild traumatic brain injury (MTBI) and general health ratings, psychosocial functioning, and perceived barriers to receiving mental healthcare 2 years following return from deployment in veterans of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF).

"Compared with respondents who screened negative for MTBI, respondents who screened positive for MTBI were younger, more likely to have PTSD, more likely to report fair/poor overall health and unmet medical and psychological needs, and scored higher on measures of psychosocial difficulties and perceived barriers to mental healthcare. Injuries involving loss of consciousness were associated with greater work-related difficulties and unmet psychological needs. PTSD mediated the relationship between MTBI and all of these outcomes." 

The researchers concluded: "These results underscore the importance of assessing PTSD in OEF/OIF veterans who screen positive for MTBI."


For additional information, contact R.H. Pietrzak, Yale University, School Medical, National Center PTSD, VA Connecticut Healthcare Systems, 950 Campbell Avenue 151E, West Haven, CT 06516, USA.
 

Back Injury Second Leading Military Disability

Interestingly, back injury is reported second to psychiatric injury as a leading cause of military personnel non-return to duty.

Military personnel evacuated out of Iraq and Afghanistan because of back pain are unlikely to return to the line of duty regardless of the treatment they receive, according to research led by a Johns Hopkins pain management specialist.

In a study published in the  Archives of Internal Medicine, researchers found that just 13 percent of service members who left their units with back pain as their primary diagnosis eventually returned to duty in the field. Women, officers, those deployed in Afghanistan and those with previous back pain had better outcomes, but only marginally. Aside from combat injuries sustained during battle, the return-to-duty rate for spinal pain and other musculoskeletal disorders is lower than for any other disease or non-combat injury category except for psychiatric illness, the researchers said.
 

Read more here.

Ashamed of War Wounds

More attention has been paid to the mental health of American troops in Iraq and Afghanistan than in any previous war. Yet shame remains a significant barrier to military personnel and their families getting the psychiatric treatment they need, a report released Wednesday says.

Time Magazine reports today on the American Psychiatric Association's study that veterans are attaching a stigma to the psychiatric afftects of the war.  This is a function of educating the public and veterans about the reality of brain and mental injury.

The good news is nearly three-quarters of the 200 military men and women interviewed by the American Psychiatric Association (APA) said that it was very or somewhat easy for them to seek out mental health care. But 60% still feared that doing so could have negative consequences on their career. More than half reported they believe others would think less of them if they sought out counseling, and most surveyed said they have rarely or never spoken even to family and friends about mental health issues. These numbers show "there's still a long way to go towards reducing the stigma surrounding care," says APA board member Dr. Mary Helen Davis.

Click here to read the whole article.