Brain Expert Sees Progress

I have read many articles and book chapters authored by Dr. Erin Bigler.  Dr. Bigler is a neuropsyhologist in Utah.  Dr. Bigler has assisted me in understanding neuroimaging along with neuropsychological issues of many of my clients.

Dr, Bigler was featured in a recent article in the Honolulu Star:

Technology to diagnose brain injuries has improved tremendously over 30 years, says Dr. Erin Bigler, noted clinical neurophysiologist.

"But the problem is we haven't made tremendous gains in how to treat these people," he added in an interview. "The brain is very complicated."

Bigler is a professor of psychology and neuroscience at Brigham Young University, adjunct professor of psychiatry at the University of Utah School of Medicine and faculty member of the Utah Brain Institute.

He is an author and researcher who is sharing his expertise with Hawaii psychologists and physicians as the Morita Distinguished Fellow for 2008 at the Rehabilitation Hospital of the Pacific.

He is also giving a class for psychology and neuropsychology fellows at Tripler Army Medical Center and a new neuroscience class at Brigham Young-Hawaii.

Bigler was at the Barrow Neurological Institute at St. Joseph's Hospital and Medical Center in Phoenix in 1975 when it was one of the first places to get computerized tomography.

"The first time I saw a CT scanner, it was like, 'Wow!'" he said. "It was very primitive, but we were now actually looking at brain tissue, not just a silhouette of the internal cavity."

Now, with improved CTs and magnetic resonance imaging, he said, "What we view today is exactly what you would see if you had an anatomic specimen."

This 3-D image shows a corpus callosum, which connects two halves of the brain. The different colors show the direction of major fiber tracks.


While the new imaging tools allow physicians to better diagnose problems in the brain, he said, "we're still in infancy in how to treat these. That's the focus that is so important right now.

"Brain tissue doesn't regenerate," he explained. "Therefore you have to deal with pathways that survive and how to re-engage those pathways. That is the goal of rehabilitation when the brain is injured."

The brain is well designed to withstand minor problems, Bigler said. "It recovers from a fall and a blow quite well. But it's a new era we're in. The brain isn't designed to withstand high-velocity impact," he said, such as from motor accidents, sports and military combat.

Gladiators were not at risk for traumatic brain injuries as much as National Football League players, he said.

An estimated 40,000 head injuries have occurred in Afghanistan and Iraq, Bigler said, noting former ABC World News co-anchor Bob Woodruff's recovery from traumatic brain injury in Iraq was "unbelievable." He said Woodruff's case shows much more could be done to treat brain injuries "if we had unlimited resources."

"Traumatic brain injury is a huge issue," he said. Many people in the past discounted effects of a mild head injury or concussion, thinking it could not have significant consequences, he said.

Most people do recover from a mild concussion, Bigler said, explaining he was knocked out playing football when he was a high school senior. He spent the night in the hospital but played the game the next weekend and went on to graduate, he said.

But more than 1 million to 1.5 million Americans have concussions, and 5 percent to 10 percent "don't have a good outcome," he said.

He said the key to knowing how to treat a brain disorder is to first understand the pathology, which is what he has been focusing on.

"When we started doing three-dimensional work with the brain ... it took us over six years to analyze the data because all of it had to be done by hand," he said. With automation, he said, his lab and others "can do in minutes to hours what would literally take us months to years to do a few years ago."

"We're looking to centers like REHAB to take the information and hopefully use it to guide therapies, to understand the brain better.

"With newer imaging techniques," Bigler said, "we may be able to target specific areas and tell how functional that area is, and there may be ways to engage that brain region" with medications, cell regeneration, cell growth stimulation, reconnections or repairing neurons.

The Morita Distinguished Fellow Program was established in 2003 in memory of SONY founder Akio Morita and his wife, Yoshiko. Morita received treatment at REHAB Hospital and became one of its major supporters.

Credit: By Helen Altonn haltonn@starbulletin.com

Brain Damage

Brain damage may occur due to a wide range of conditions, illnesses, injuries, and as a result of iatrogenesis. Possible causes of widespread (diffuse) brain damage include prolonged hypoxia (shortage of oxygen), poisoning by teratogens (including alcohol), infection, and neurological illness. Chemotherapy can cause brain damage to the neural stem cells and oligodendrocyte cells that produce myelin. Common causes of focal or localized brain damage are physical trauma (traumatic brain injury), stroke, aneurysm, surgery, or neurological illness.

The extent and effect of brain injury is often assessed by the use of neurological examination, neuroimaging, and neuropsychological assessment.

Brain injury does not necessarily result in long-term impairment or disability, although the location and extent of damage both have a significant effect on the likely outcome. In serious cases of brain injury, the result can be permanent disability, including neurocognitive deficits, delusions (often specifically monothematic delusions), speech or movement problems, and mental handicap. There may also be personality changes. Severe brain damage may result in persistent vegetative state, coma, or death.

Various professions may be involved in the medical care and rehabilitation of someone who suffers impairment after brain damage. Neurologists, neurosurgeons, and physiatrists are physicians who specialise in treating brain injury. Neuropsychologists (especially clinical neuropsychologists) are psychologists who specialise in understanding the effects of brain injury and may be involved in assessing the extent of brain damage or creating rehabilitation programmes. Occupational therapists may be involved in running rehabilitation programs to help restore lost function or help re-learn essential skills.

It is a common misconception that brain damage sustained during childhood has a better chance of successful recovery than similar injury acquired in adult life. It is contested that in recent studies, severe brain damage inflicted upon children can be alleviated by the interaction of nicotinamide repropagation in nerve cells. In fact, the consequences of childhood injury may simply be more difficult to detect in the short term. This is because different cortical areas mature at different stages, with some major cell populations and their corresponding cognitive faculties remaining unrefined until early adulthood. In the case of a child with frontal brain injury, for example, the impact of the damage may be undetectable until that child fails to develop normal executive functions in his or her late teens and early twenties.

The effects of impairment or disability resulting from brain injury may be treated by a number of methods, including medication, psychotherapy, neuropsychological rehabilitation, snoezelen, surgery, or physical implants such as deep brain stimulation.

Neuroimaging

I came across this brief explanantion of some of the topics I will be presenting with Dr. Joseph Wu of University of California, Irvine, in next week's Brain Injury Association of America Conference in Las Vegas.  Here CT, MRI,fMRI, Spect and PET are discussed.  These diagnostics show us the structure and metabolism of the brain.  EEG (not discussed below) reveals electrical activity of the brain.

Dr. Wu is the Director of the Brain Imaging Center and will be discussing advances in Positron Emission Tomography technology and use in brain injury detection.  This information was derived from Microsoft® Encarta® Online Encyclopedia 2007:

Brain Imaging

Several commonly used diagnostic methods give images of the brain without invading the skull. Some portray anatomy—that is, the structure of the brain—whereas others measure brain function. Two or more methods may be used to complement each other, together providing a more complete picture than would be possible by one method alone.

Magnetic resonance imaging (MRI), introduced in the early 1980s, beams high-frequency radio waves into the brain in a highly magnetized field that causes the protons that form the nuclei of hydrogen atoms in the brain to reemit the radio waves. The reemitted radio waves are analyzed by computer to create thin cross-sectional images of the brain. MRI provides the most detailed images of the brain and is safer than imaging methods that use X rays. However, MRI is a lengthy process and also cannot be used with people who have pacemakers or metal implants, both of which are adversely affected by the magnetic field.

Computed tomography (CT), also known as CT scans, developed in the early 1970s. This imaging method X-rays the brain from many different angles, feeding the information into a computer that produces a series of cross-sectional images. CT is particularly useful for diagnosing blood clots and brain tumors. It is a much quicker process than magnetic resonance imaging and is therefore advantageous in certain situations—for example, with people who are extremely ill.

Changes in brain function due to brain disorders can be visualized in several ways. Magnetic resonance spectroscopy measures the concentration of specific chemical compounds in the brain that may change during specific behaviors. Functional magnetic resonance imaging (fMRI) maps changes in oxygen concentration that correspond to nerve cell activity.

Positron emission tomography (PET), developed in the mid-1970s, uses computed tomography to visualize radioactive tracers (see Isotopic Tracer), radioactive substances introduced into the brain intravenously or by inhalation. PET can measure such brain functions as cerebral metabolism, blood flow and volume, oxygen use, and the formation of neurotransmitters. Single photon emission computed tomography (SPECT), developed in the 1950s and 1960s, uses radioactive tracers to visualize the circulation and volume of blood in the brain.

Brain-imaging studies have provided new insights into sensory, motor, language, and memory processes, as well as brain disorders such as epilepsy; cerebrovascular disease; Alzheimer's, Parkinson, and Huntington's diseases (see Chorea); and various mental disorders, such as schizophrenia.

Cost of Neuroimaging

Insurance companies are once again trying to preserve their income by cutting health care.  The rising cost of CT and other neuroimaging techniques is prompting insurance companies to look for ways to decrease their use.

There is certainly an argument that doctors have been placed in the unenviable position of having to protect themselves by practicing "defensive medicine."  But more compelling is the information neuroimaging provides in saving lives or prescribing proper care.

It is no wonder that diagnostic tests increase as technology increases.  Moreover, doctors' ability to see and treat disease increases with the use of neuroimaging technology.  Just as the Hubbell telescope  allows us to see things in outer space previously unseen and allows us to create theories of Relativity, we are better informed and able to understand that sun does not evolve around earth but earth around sun.

Fortunately health insurance companies do not dispute such theories and facts - but if they could save money doing it I bet they would!

Read the article in today's Newsday.

To read more click Study by Center for Studying Health System Change http://hschange.org/CONTENT/968/